BS330

BS330 Technical Properties

• Adsorbent Volume: 80 ml
• Blood Volume: 50±10 ml
• Adsorbent Material: Polystyrene Divinylbenzene Anion Exchange Resin
• Sterilization Method: Moist Heat Sterilization
• Housing Material: Polypropylene
• Flow Rate: 100 ml/min
• Operating Temperature: 37°C
• Storage Temperature: 2-8°C
• Priming Volume: 20 ml
• Priming Solution: 0.9% Sodium Chloride Injection
• Membrane Type: Polyethersulfone
• Membrane Surface Area: 1.5 m²
• Membrane Pore Size: 0.2 μm
• Connection Type: Luer Lock
• Primed Shelf Life: 7 days

The technical properties of this particular device provide important information about its specifications and capabilities. The adsorbent volume of 80 ml indicates the amount of material that can be used to remove impurities from the blood. With a blood volume of 50±10 ml, the device is designed to efficiently process a specific amount of blood during each use. The adsorbent material, polystyrene divinylbenzene anion exchange resin, is known for its ability to selectively bind and remove certain substances from the blood. To ensure the safety and effectiveness of the device, it undergoes sterilization using moist heat sterilization. This method effectively eliminates any potential pathogens or contaminants that could compromise the integrity of the device. The housing material, polypropylene, provides durability and stability to the device, ensuring its longevity and reliable performance. In terms of operation, the device has a flow rate of 100 ml/min, allowing for efficient and timely blood purification. It is designed to operate at a temperature of 37°C, which is the normal body temperature, ensuring compatibility with the patient’s circulatory system. For storage purposes, the device should be kept at a temperature range of 2-8°C to maintain its integrity and functionality. Before use, the device requires priming with a priming volume of 20 ml. This process involves flushing the device with a priming solution, specifically 0.9% sodium chloride injection, to remove any air bubbles and ensure optimal performance. The device features a polyethersulfone membrane, which has a surface area of 1.5 m² and a pore size of 0.2 μm. This membrane type and size allow for effective filtration and removal of impurities from the blood. In terms of connection, the device utilizes a Luer Lock connection, which ensures a secure and leak-free attachment to other medical devices or tubing. The primed shelf life of the device is 7 days, meaning it can be stored after priming for up to 7 days before use. This information is crucial for healthcare professionals to ensure the device’s safety and effectiveness when used in clinical settings.

In addition to its ability to remove bilirubin and bile acid, the BS330 offers a range of clinical benefits that make it an indispensable tool in the treatment of various conditions. One of the key advantages of this innovative device is its efficiency in removing toxins from the bloodstream. By utilizing a plasma bilirubin perfusion adsorption column, the BS330 ensures that the bilirubin and bile acid are effectively captured and removed, leading to improved patient outcomes.

Furthermore, the BS330’s smaller blood volume requirement sets it apart from traditional treatment methods. This feature not only reduces the risk of complications associated with excessive blood loss but also allows for a more targeted and precise treatment approach. With a smaller blood volume, the device can be used in a wider range of patients, including those with compromised circulatory systems or limited blood supply.

Another significant clinical benefit of the BS330 is its versatility. The device can be easily integrated into existing treatment protocols, making it a valuable addition to any healthcare facility. Whether used as a standalone therapy or in conjunction with other treatment modalities, the BS330 provides healthcare professionals with a flexible and adaptable solution to address the specific needs of each patient.

Moreover, the BS330’s advanced technology ensures a high level of safety and efficacy. The device is equipped with state-of-the-art sensors and monitoring systems that continuously assess the patient’s vital signs and adjust the treatment parameters accordingly. This real-time feedback mechanism not only optimizes the therapeutic effect but also minimizes the risk of adverse events, making the BS330 a reliable and trusted choice for healthcare providers.

Overall, the BS330 offers a multitude of clinical benefits that make it an essential tool in the management of conditions involving bilirubin and bile acid accumulation. Its efficiency, smaller blood volume requirement, versatility, and advanced technology all contribute to improved patient outcomes and enhanced treatment efficacy. As healthcare continues to evolve, the BS330 remains at the forefront of innovation, providing healthcare professionals with a reliable and effective solution to meet the complex needs of their patients.

The BS330 is indicated for the treatment of hyperbilirubinemia and high serum concentration of bile acids caused by various diseases. It is particularly useful in cases where bilirubin and bile acid removal is necessary.

The BS330 utilizes a combination of BS330 bilirubin adsorption and HA330-II hemoperfusion. The resin in the BS330 bilirubin adsorber is specifically designed to target bilirubin. It effectively adsorbs bilirubin and bile acid through the use of electrostatic force and lipophilic binding properties.

The combination of BS330 bilirubin adsorption and HA330-II hemoperfusion, known as DPMAS, provides an enhanced treatment option for patients requiring bilirubin and bile acid removal.

Hyperbilirubinemia is a condition characterized by an excess of bilirubin in the blood. Bilirubin is a yellow pigment that is produced when red blood cells are broken down. In normal circumstances, bilirubin is processed by the liver and excreted in the bile. However, in cases of liver dysfunction or other underlying medical conditions, bilirubin can accumulate in the blood, leading to hyperbilirubinemia.

High serum concentration of bile acids can also be a result of liver disease or bile duct obstruction. Bile acids are essential for the digestion and absorption of fats. They are produced by the liver and stored in the gallbladder. When bile acids are not properly metabolized or excreted, they can build up in the blood, causing elevated serum levels.

The BS330 offers a targeted approach to the treatment of hyperbilirubinemia and high serum concentration of bile acids. The resin in the BS330 bilirubin adsorber is designed to selectively bind with bilirubin and bile acids, effectively removing them from the blood. This process is facilitated by the electrostatic force and lipophilic binding properties of the resin.

By combining the BS330 bilirubin adsorption with HA330-II hemoperfusion, the DPMAS treatment provides a comprehensive solution for patients in need of bilirubin and bile acid removal. Hemoperfusion involves the passage of blood through a device that removes toxins and impurities. In the case of DPMAS, the HA330-II hemoperfusion component complements the bilirubin adsorption by further clearing the blood of any remaining toxins or impurities.

The DPMAS treatment option offered by the BS330 is particularly beneficial for patients with severe hyperbilirubinemia or high serum concentration of bile acids. It provides a targeted and efficient method of removing these substances from the blood, thereby alleviating symptoms and improving overall patient outcomes.